CHOLESTEROL

Cholesterol plays essential roles in the human body, serving as a fundamental component of cell membranes and a precursor for hormones, vitamin D, and other bioactive molecules.

However, dysregulation of cholesterol homeostasis and excessive intracellular accumulation of cholesterol can lead to cholesterol-induced toxicities, which are increasingly recognized as key contributors to various age-related and metabolic diseases, including chronic kidney disease, neurodegenerative disorders, MASH, and atherosclerosis.

Aging, diabetes, and genetic factors are major drivers of cholesterol metabolic dysfunction, leading to pathological cholesterol accumulation and subsequent cellular and tissue damage.